Augmentation of vaccine-induced humoral and cellular immunity by a physical radiofrequency adjuvant.
Identifieur interne : 000A20 ( Main/Exploration ); précédent : 000A19; suivant : 000A21Augmentation of vaccine-induced humoral and cellular immunity by a physical radiofrequency adjuvant.
Auteurs : Yan Cao [États-Unis] ; Xiaoyue Zhu [États-Unis] ; Md Nazir Hossen [États-Unis] ; Prateek Kakar [États-Unis] ; Yiwen Zhao [États-Unis] ; Xinyuan Chen [États-Unis]Source :
- Nature communications [ 2041-1723 ] ; 2018.
Descripteurs français
- KwdFr :
- Adjuvants immunologiques, Animaux, Immunité cellulaire (immunologie), Immunité cellulaire (physiologie), Immunité humorale (immunologie), Immunité humorale (physiologie), Mâle, Souris, Souris de lignée BALB C, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (immunologie), Technique de Western, Vaccins antigrippaux (immunologie).
- MESH :
English descriptors
- KwdEn :
- Adjuvants, Immunologic, Animals, Blotting, Western, Immunity, Cellular (immunology), Immunity, Cellular (physiology), Immunity, Humoral (immunology), Immunity, Humoral (physiology), Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines (immunology), Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL.
- MESH :
- chemical , immunology : Influenza Vaccines.
- chemical : Adjuvants, Immunologic.
- immunology : Immunity, Cellular, Immunity, Humoral, Influenza A Virus, H1N1 Subtype.
- physiology : Immunity, Cellular, Immunity, Humoral.
- Animals, Blotting, Western, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL.
Abstract
Protein/subunit vaccines often require external adjuvants to induce protective immunity. Due to the safety concern of chemical adjuvants, physical adjuvants were recently explored to boost vaccination. Physical adjuvants use physical energies rather than chemicals to stimulate tissue stress and endogenous danger signal release to boost vaccination. Here we present the safety and potency of non-invasive radiofrequency treatment to boost intradermal vaccination in murine models. We show non-invasive radiofrequency can increase protein antigen-induced humoral and cellular immune responses with adjuvant effects comparable to widely used chemical adjuvants. Radiofrequency adjuvant can also safely boost pandemic 2009 H1N1 influenza vaccination with adjuvant effects comparable to MF59-like AddaVax adjuvant. We find radiofrequency adjuvant induces heat shock protein 70 (HSP70) release and activates MyD88 to mediate the adjuvant effects. Physical radiofrequency can potentially be a safe and potent adjuvant to augment protein/subunit vaccine-induced humoral and cellular immune responses.
DOI: 10.1038/s41467-018-06151-y
PubMed: 30209303
Affiliations:
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cellulaire (physiologie)</term><term>Immunité humorale (immunologie)</term><term>Immunité humorale (physiologie)</term><term>Mâle</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Technique de Western</term><term>Vaccins antigrippaux (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adjuvants, Immunologic</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité cellulaire</term><term>Immunité humorale</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immunity, Cellular</term><term>Immunity, Humoral</term><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Immunité cellulaire</term><term>Immunité humorale</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Immunity, Cellular</term><term>Immunity, Humoral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Mice, Inbred C57BL</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adjuvants immunologiques</term><term>Animaux</term><term>Mâle</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Souris de lignée C57BL</term><term>Technique de Western</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Protein/subunit vaccines often require external adjuvants to induce protective immunity. Due to the safety concern of chemical adjuvants, physical adjuvants were recently explored to boost vaccination. Physical adjuvants use physical energies rather than chemicals to stimulate tissue stress and endogenous danger signal release to boost vaccination. Here we present the safety and potency of non-invasive radiofrequency treatment to boost intradermal vaccination in murine models. We show non-invasive radiofrequency can increase protein antigen-induced humoral and cellular immune responses with adjuvant effects comparable to widely used chemical adjuvants. Radiofrequency adjuvant can also safely boost pandemic 2009 H1N1 influenza vaccination with adjuvant effects comparable to MF59-like AddaVax adjuvant. We find radiofrequency adjuvant induces heat shock protein 70 (HSP70) release and activates MyD88 to mediate the adjuvant effects. Physical radiofrequency can potentially be a safe and potent adjuvant to augment protein/subunit vaccine-induced humoral and cellular immune responses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Cao, Yan" sort="Cao, Yan" uniqKey="Cao Y" first="Yan" last="Cao">Yan Cao</name></noRegion><name sortKey="Chen, Xinyuan" sort="Chen, Xinyuan" uniqKey="Chen X" first="Xinyuan" last="Chen">Xinyuan Chen</name><name sortKey="Hossen, Md Nazir" sort="Hossen, Md Nazir" uniqKey="Hossen M" first="Md Nazir" last="Hossen">Md Nazir Hossen</name><name sortKey="Kakar, Prateek" sort="Kakar, Prateek" uniqKey="Kakar P" first="Prateek" last="Kakar">Prateek Kakar</name><name sortKey="Zhao, Yiwen" sort="Zhao, Yiwen" uniqKey="Zhao Y" first="Yiwen" last="Zhao">Yiwen Zhao</name><name sortKey="Zhu, Xiaoyue" sort="Zhu, Xiaoyue" uniqKey="Zhu X" first="Xiaoyue" last="Zhu">Xiaoyue Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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